Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.38 |
| ▸ | PDE6C | P51160 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | PDE1A | P54750 | 2/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.35 |
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
| ▸ | PDE8A | O60658 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7950670 | 0.81 | KDM4E (0.46) | PDE5APDE6CKMT2AKDM4EHDAC6 | |
| SCHEMBL6249380 | 0.77 | PDE5A (0.42) | PDE5APDE6CKMT2AKDM4EHDAC6 | |
| SCHEMBL7962779 | 0.76 | PDE5A (0.66) | PDE5APDE6CKMT2AKDM4EHDAC6 | |
| SCHEMBL7962777 | 0.76 | PDE5A (0.66) | PDE5APDE6CKMT2AKDM4EHDAC6 | |
| SCHEMBL7019550 | 0.75 | PDE5A (0.46) | PDE5APDE6CKMT2AHDAC6HDAC1 | |
| SCHEMBL3671938 | 0.75 | PDE5A (0.63) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL7778185 | 0.74 | PDE5A (0.54) | PDE5APDE6CHDAC6HDAC1PDE1A | |
| SCHEMBL14685954 | 0.74 | KDM4E (0.48) | PDE5APDE6CKMT2AKDM4EHDAC6 | |
| SCHEMBL7446947 | 0.73 | ALDH1A1 (0.46) | PDE5APDE6CKMT2AKDM4EPDE1A | |
| SCHEMBL7360293 | 0.72 | ALDH1A1 (0.39) | PDE5APDE6CKMT2AKDM4EHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |