Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953575 | 1.00 | ADRB2 (0.50) | ADRB2ADRB1ADRB3SMN1; SMN2PRMT5 | |
| SCHEMBL27193282 | 0.89 | SMN1; SMN2 (0.57) | SMN1; SMN2PRMT5WDR77KDM4EMAPT | |
| SCHEMBL7200720 | 0.89 | SMN1; SMN2 (0.57) | SMN1; SMN2PRMT5WDR77KDM4EMAPT | |
| SCHEMBL7962982 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2PRMT5WDR77KDM4EMAPT | |
| SCHEMBL7966189 | 0.86 | LTA4H (0.50) | HTR1A | |
| SCHEMBL7969553 | 0.85 | L3MBTL1 (0.55) | SMN1; SMN2PRMT5WDR77HTR1AKDM4E | |
| SCHEMBL7953581 | 0.84 | DRD2 (0.42) | ADRB2ADRB1ADRB3HTR1A | |
| SCHEMBL7969477 | 0.84 | MAPT (0.50) | SMN1; SMN2PRMT5WDR77KDM4EMAPT | |
| SCHEMBL7953370 | 0.83 | HTR1A (0.56) | ADRB2ADRB1ADRB3HTR1A | |
| SCHEMBL7953568 | 0.83 | LTA4H (0.41) | ADRB2ADRB1ADRB3PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |