Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 3/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.34 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.34 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.34 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967096 | 0.90 | TUBB4A (0.38) | OPRL1SLC6A1SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL8139378 | 0.87 | SLC6A1 (0.34) | OPRL1KDM4EKMT2AMEN1CCR1 | |
| SCHEMBL7962999 | 0.87 | OPRL1 (0.40) | OPRL1CCR1HTR1AOPRM1 | |
| SCHEMBL7963100 | 0.87 | SLC6A1 (0.34) | OPRL1KDM4EKMT2AMEN1CCR1 | |
| SCHEMBL7965451 | 0.80 | SMN1; SMN2 (0.55) | KDM4EKMT2AMEN1HTR1ACYP3A4 | |
| SCHEMBL7965345 | 0.80 | SLC6A1 (0.34) | OPRL1SLC6A1SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL7965744 | 0.79 | HTR1A (0.36) | SLC6A1SLC6A12SLC6A11SLC6A13HTR1A | |
| SCHEMBL7967126 | 0.79 | ABCB1 (0.39) | DRD3 | |
| SCHEMBL7200725 | 0.78 | OPRL1 (0.41) | OPRL1KDM4EKMT2AMEN1CCR1 | |
| SCHEMBL7965447 | 0.78 | HRH3 (0.36) | KDM4EHRH3HRH1DRD3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |