Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 2/20 | 0.34 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.34 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.34 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.34 |
| ▸ | TACR2 | P21452 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139378 | 1.00 | SLC6A1 (0.34) | SLC6A1SLC6A12SLC6A11SLC6A13TACR2 | |
| SCHEMBL7962999 | 0.91 | OPRL1 (0.40) | OPRL1OPRM1OPRD1CCR1HTR1A | |
| SCHEMBL7965454 | 0.87 | OPRL1 (0.36) | SLC6A1SLC6A12SLC6A11SLC6A13TACR2 | |
| SCHEMBL7967096 | 0.83 | TUBB4A (0.38) | SLC6A1SLC6A12SLC6A11SLC6A13OPRL1 | |
| SCHEMBL7963099 | 0.82 | KMT2A (0.49) | KDM4EMEN1USP2HTR1ACYP2D6 | |
| SCHEMBL7963097 | 0.80 | HRH3 (0.36) | HRH3KDM4EMEN1LMNAKMT2A | |
| SCHEMBL7965755 | 0.79 | TACR2 (0.40) | TACR2HRH3OPRL1KDM4EOPRM1 | |
| SCHEMBL7965345 | 0.77 | SLC6A1 (0.34) | SLC6A1SLC6A12SLC6A11SLC6A13OPRL1 | |
| SCHEMBL7965744 | 0.76 | HTR1A (0.36) | SLC6A1SLC6A12SLC6A11SLC6A13HTR1A | |
| SCHEMBL7963764 | 0.76 | MEN1 (0.35) | SLC6A1SLC6A12SLC6A11CYP11B2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |