Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.36 |
| ▸ | DRD2 | P14416 | 5/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.35 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.35 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.35 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962445 | 0.85 | HTR1A (0.42) | HTR1AHTR2AHTR7HTR6SLC6A4 | |
| SCHEMBL7965741 | 0.83 | HTR1A (0.54) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL7964964 | 0.82 | HTR1A (0.47) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7953373 | 0.81 | HTR1A (0.40) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL7965737 | 0.81 | HTR1A (0.41) | HTR1ADRD2SLC6A4DRD4DRD3 | |
| SCHEMBL7953976 | 0.81 | SLC6A2 (0.38) | HTR1ADRD2SLC6A4DRD4DRD3 | |
| SCHEMBL7965454 | 0.79 | OPRL1 (0.36) | HTR1ADRD3SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL7965345 | 0.78 | SLC6A1 (0.34) | DRD2SLC6A4DRD4DRD3SLC6A1 | |
| SCHEMBL7963100 | 0.76 | SLC6A1 (0.34) | HTR1ADRD2HTR2AHTR6SLC6A4 | |
| SCHEMBL8139378 | 0.76 | SLC6A1 (0.34) | HTR1ADRD2HTR2AHTR6SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |