Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962445 | 0.85 | HTR1A (0.42) | HTR1ASLC6A4MCL1DRD4DRD3 | |
| SCHEMBL7965741 | 0.83 | HTR1A (0.54) | HTR1ASLC6A4ADRB2ADRB1 | |
| SCHEMBL7953366 | 0.82 | HTR1A (0.43) | HTR1ASLC6A4HTR1BADRB2ADRB1 | |
| SCHEMBL7964956 | 0.82 | HTR1A (0.47) | HTR1ASLC6A4 | |
| SCHEMBL7965744 | 0.81 | HTR1A (0.36) | HTR1ASLC6A4DRD2DRD4DRD3 | |
| SCHEMBL7953971 | 0.81 | OPRM1 (0.33) | SLC6A4 | |
| SCHEMBL7965447 | 0.79 | HRH3 (0.36) | SLC6A4DRD3 | |
| SCHEMBL7965338 | 0.79 | OPRM1 (0.31) | DRD2DRD4DRD3 | |
| Succinic Acid SCHEMBL7965776 | 0.77 | ITGA4 (0.34) | HTR1ADRD2 | |
| Phenylacetic Acid SCHEMBL7961720 | 0.77 | P2RX7 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |