Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966082 | 0.86 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2LMNAKMT2A | |
| Oxalic Acid SCHEMBL7966526 | 0.78 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL7962445 | 0.77 | HTR1A (0.42) | KMT2AMEN1HRH3 | |
| SCHEMBL7965454 | 0.74 | OPRL1 (0.36) | KDM4EKMT2AMEN1HRH3HRH1 | |
| SCHEMBL11717047 | 0.73 | ALDH1A1 (0.74) | KDM4EALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL7962754 | 0.72 | ALDH1A1 (0.56) | KDM4EALDH1A1SMN1; SMN2LMNAKMT2A | |
| Acrylic Acid SCHEMBL7963757 | 0.72 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL7964475 | 0.72 | CYP11B2 (0.41) | ALDH1A1KMT2AMEN1 | |
| Oxalic Acid SCHEMBL5856230 | 0.72 | KDM4E (1.00) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28396299 | 0.71 | CYP11B2 (0.43) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |