Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 8/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.37 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.36 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964478 | 0.78 | CYP11B2 (0.62) | CYP11B2CYP11B1 | |
| SCHEMBL28396299 | 0.76 | CYP11B2 (0.43) | CYP11B2CYP11B1ITGA4ITGB7 | |
| SCHEMBL8139378 | 0.74 | SLC6A1 (0.34) | CYP11B2SLC6A1SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL7963099 | 0.74 | KMT2A (0.49) | MEN1ALDH1A1KMT2A | |
| SCHEMBL7963100 | 0.74 | SLC6A1 (0.34) | CYP11B2SLC6A1SLC6A12SLC6A11SLC6A13 | |
| Oxalic Acid SCHEMBL7966080 | 0.72 | KDM4E (0.54) | MEN1ALDH1A1KMT2A | |
| SCHEMBL8879291 | 0.71 | HTR2A (0.39) | CYP11B2CYP11B1SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL7965451 | 0.70 | SMN1; SMN2 (0.55) | MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL7965454 | 0.70 | OPRL1 (0.36) | SLC6A1SLC6A12SLC6A11SLC6A13DRD3 | |
| SCHEMBL7964139 | 0.70 | CYP11B1 (0.46) | CYP11B2CYP11B1DRD2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |