Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 9/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959052 | 0.89 | HPSE (0.42) | MEN1MAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7969314 | 0.87 | KMT2A (0.56) | MEN1MAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7957018 | 0.86 | CSF1R (0.52) | MEN1MAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7968563 | 0.85 | RAB9A (0.55) | MEN1MAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7955623 | 0.85 | NPC1 (0.50) | MEN1MAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7966117 | 0.84 | RAF1 (0.48) | MEN1MAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7975298 | 0.83 | MAPT (0.55) | MEN1MAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7955626 | 0.83 | MEN1 (0.55) | MEN1MAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7959068 | 0.83 | NR1H4 (0.44) | MEN1MAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7967465 | 0.82 | MAPT (0.56) | MEN1MAPTKMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |