Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 2/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7973003 | 0.94 | MEN1 (0.48) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL7969314 | 0.89 | KMT2A (0.56) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL7964851 | 0.89 | CNR1 (0.55) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL7957018 | 0.88 | CSF1R (0.52) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL7975298 | 0.87 | MAPT (0.55) | RAB9AKMT2AMEN1MAPTGAA | |
| SCHEMBL7966117 | 0.86 | RAF1 (0.48) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL7955626 | 0.85 | MEN1 (0.55) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL7969958 | 0.85 | MEN1 (0.48) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL7971214 | 0.85 | SMN1; SMN2 (0.46) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL7967465 | 0.84 | MAPT (0.56) | RAB9AKMT2AMEN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |