Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975298 | 0.90 | MAPT (0.55) | MAPTRAB9ASMN1; SMN2HTTLMNA | |
| SCHEMBL7969314 | 0.88 | KMT2A (0.56) | MAPTRAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL7957018 | 0.87 | CSF1R (0.52) | MAPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL7968563 | 0.86 | RAB9A (0.55) | MAPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL7955626 | 0.84 | MEN1 (0.55) | MAPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL7969958 | 0.84 | MEN1 (0.48) | MAPTRAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL7968196 | 0.83 | MAPT (0.51) | RAF1MAPTRAB9ASMN1; SMN2HTT | |
| SCHEMBL7967465 | 0.83 | MAPT (0.56) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7969315 | 0.82 | CA2 (0.54) | MAPTRAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL7973003 | 0.82 | MEN1 (0.48) | MAPTRAB9ANPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |