Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9979672 | 0.88 | PLA2G4A (0.43) | PLA2G4AALDH1A1ATMKDM4ETNF | |
| SCHEMBL3689068 | 0.83 | F2 (0.45) | ALDH1A1ATMKDM4ETNFMAPT | |
| SCHEMBL30396580 | 0.83 | F2 (0.45) | ALDH1A1ATMKDM4ETNFMAPT | |
| SCHEMBL4485443 | 0.82 | NTSR1 (0.52) | ALDH1A1ATMLMNAMEN1KMT2A | |
| SCHEMBL1666483 | 0.82 | NTSR1 (0.52) | ALDH1A1ATMTNFMAPTLMNA | |
| SCHEMBL20037218 | 0.82 | TDP1 (0.53) | ALDH1A1ATMMAPTLMNAPDE4B | |
| SCHEMBL29138523 | 0.82 | MTNR1A (0.56) | ALDH1A1ATMKDM4ETNFMAPT | |
| SCHEMBL4483940 | 0.82 | ATM (0.43) | ALDH1A1ATMKDM4ETNFMAPT | |
| SCHEMBL20037274 | 0.82 | ALDH1A1 (0.50) | ALDH1A1ATMKDM4ETNF | |
| SCHEMBL19777848 | 0.81 | ALDH1A1 (0.46) | ALDH1A1ATMKDM4ETNFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200978-B1 | FOR PREVENTING OR TREATING INFLAMMATORY DISEASES SUCH AS ARTHRITIS, PSORIASIS, ASTHMA, OR INFLAMMATORY BOWEL DISEASE, DISORDERS OF RESPIRATORY FUNCTION, GASTROINTESTINAL DISORDERS SUCH AS FUNCTIONAL BOWEL DISEASE, AS ANALGESICS | PFIZER INC. | 2001-03-13 | — | — | US | disclosed |