Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | NOX1 | Q9Y5S8 | 10/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | GAA | P10253 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | SNCA | P37840 | 3/20 | 0.61 |
| ▸ | BCHE | P06276 | 2/20 | 0.61 |
| ▸ | ACHE | P22303 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | CNR1 | P21554 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9007318 | 0.81 | ALDH1A1 (0.68) | ALDH1A1NOX1MAPTGAAMEN1 | |
| SCHEMBL9007315 | 0.79 | NOX1 (0.66) | ALDH1A1NOX1MAPTGAAMEN1 | |
| SCHEMBL9007310 | 0.78 | ALDH1A1 (0.63) | ALDH1A1NOX1MAPTGAAMEN1 | |
| SCHEMBL9007359 | 0.78 | NOX1 (0.68) | ALDH1A1NOX1MAPTGAAMEN1 | |
| SCHEMBL9007338 | 0.78 | MAPT (0.68) | ALDH1A1NOX1MAPTGAAMEN1 | |
| Phenothiazine SCHEMBL6315328 | 0.78 | NOX1 (1.00) | ALDH1A1NOX1MAPTGAAMEN1 | |
| Phenothiazine SCHEMBL2504207 | 0.78 | NOX1 (1.00) | ALDH1A1NOX1MAPTGAAMEN1 | |
| Phenothiazine SCHEMBL29349533 | 0.78 | NOX1 (1.00) | ALDH1A1NOX1MAPTGAAMEN1 | |
| Phenothiazine SCHEMBL9114 | 0.78 | NOX1 (1.00) | ALDH1A1NOX1MAPTGAAMEN1 | |
| Phenothiazine SCHEMBL29352248 | 0.78 | NOX1 (1.00) | ALDH1A1NOX1MAPTGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048876-B2 | Process for preparing quetiapine and quetiapine fumarate | MEDICHEM S.A. (ES) | 2011-11-01 | — | — | US | disclosed |
| US-8048876-B2 | Process for preparing quetiapine and quetiapine fumarate | MEDICHEM S.A. (ES) | 2011-11-01 | — | — | US | disclosed |
| US-7902355-B2 | Condensation of 10H-dibenzo-[b,f][1,4]-thiazepin-11-one with a piperazine derivative in the presence of a titanium alkoxide catalyst; Titanium catalyst easier to handle, have low toxicity, not chlorinated, much less harmful for the environment | UNION QUIMICO-FARMACEUTICA S.A. (ES) | 2011-03-08 | — | — | US | disclosed |
| US-7902355-B2 | Condensation of 10H-dibenzo-[b,f][1,4]-thiazepin-11-one with a piperazine derivative in the presence of a titanium alkoxide catalyst; Titanium catalyst easier to handle, have low toxicity, not chlorinated, much less harmful for the environment | UNION QUIMICO-FARMACEUTICA S.A. (ES) | 2011-03-08 | — | — | US | disclosed |
| EP-1856073-B1 | A PROCESS FOR THE PREPARATION OF AN 11-(4-SUBSTITUTED-I-PIPERAZINYL)DIBENZO[b,f][1,4]THIAZEPINE DERIVATIVE | UNION QUIMICO FARMA (ES) | 2010-05-12 | — | — | EP | disclosed |
| US-20090076262-A1 | PROCESS FOR PREPARING QUETIAPINE AND QUETIAPINE FUMARATE | MEDICHEM, S.A. (ES) | 2009-03-19 | — | — | US | disclosed |
| US-20090076262-A1 | PROCESS FOR PREPARING QUETIAPINE AND QUETIAPINE FUMARATE | MEDICHEM, S.A. (ES) | 2009-03-19 | — | — | US | disclosed |
| US-20080171869-A1 | Process For The Preparation Of An 11-(4-Substituted-I- Piperazinyl)Dibenzo[B,F][1,4:rsqb; Thiazepine Derivative | UNION QUIMICO-FARMACEUTICA S.A. (ES) | 2008-07-17 | — | — | US | disclosed |
| US-20080171869-A1 | Process For The Preparation Of An 11-(4-Substituted-I- Piperazinyl)Dibenzo[B,F][1,4:rsqb; Thiazepine Derivative | UNION QUIMICO-FARMACEUTICA S.A. (ES) | 2008-07-17 | — | — | US | disclosed |
| US-6214820-B1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | NOVO NORDISK A/S (DK) | 2001-04-10 | — | — | US | disclosed |
| US-5589474-A | Dibenzothiazepinthione as antiviral agents | GLAXO WELLCOME INC. (US) | 1996-12-31 | — | — | US | disclosed |
| EP-0583317-A1 | DIBENZOTHIAZEPINTHIONE AS ANTIVIRAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-23 | — | — | EP | disclosed |
| WO-1992019607-A1 | DIBENZOTHIAZEPINTHIONE AS ANTIVIRAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171869-A1 | Process For The Preparation Of An 11-(4-Substituted-I- Piperazinyl)Dibenzo[B,F][1,4:rsqb; Thiazepine Derivative | SDHB, SDHA, CYP2F1 | ALDH1A1 513/4885NOX1 2105/4885MAPT 2862/4885 |
| US-20090076262-A1 | PROCESS FOR PREPARING QUETIAPINE AND QUETIAPINE FUMARATE | CYP2F1, FH, FAH | ALDH1A1 618/4885NOX1 2375/4885MAPT 535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.