Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | RBP4 | P02753 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983470 | 0.95 | SIGMAR1 (0.59) | SIGMAR1KMT2ARAB9AMEN1ALDH1A1 | |
| SCHEMBL10274715 | 0.83 | RBP4 (0.66) | SIGMAR1KMT2ARAB9AMEN1ALDH1A1 | |
| SCHEMBL7986047 | 0.82 | CKS1B (0.57) | KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL13039955 | 0.81 | SIGMAR1 (0.59) | SIGMAR1KMT2ARAB9AMEN1ALDH1A1 | |
| SCHEMBL27495677 | 0.80 | SIGMAR1 (0.55) | SIGMAR1KMT2ARAB9AMEN1ALDH1A1 | |
| SCHEMBL1329658 | 0.78 | TSHR (0.62) | SIGMAR1KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL8527250 | 0.77 | NCF1 (0.52) | SIGMAR1KMT2ARAB9AMEN1ALDH1A1 | |
| SCHEMBL7981893 | 0.77 | GAA (0.56) | ALDH1A1GAA | |
| SCHEMBL4472678 | 0.76 | TSHR (0.60) | SIGMAR1KMT2ARAB9AMEN1ALDH1A1 | |
| SCHEMBL7971891 | 0.76 | SIGMAR1 (0.80) | SIGMAR1KMT2AMEN1TSHRDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |