SCHEMBL7973087

SCHEMBL7973087

COC1=C(OC)C(=O)C2=C(CC(CCCCOc3ccc(C(=O)N4CCOCC4)cc3)C2)C1=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
HRH3 Q9Y5N1 10/20 0.52
CHRM2 P08172 1/20 0.52
CHRM1 P11229 1/20 0.52
ADRA2C P18825 1/20 0.52
CHRM3 P20309 1/20 0.52
DRD4 P21917 1/20 0.52
SLC6A2 P23975 1/20 0.52
HRH2 P25021 1/20 0.52
SLC6A4 P31645 1/20 0.52
HRH1 P35367 1/20 0.52
SLC6A3 Q01959 1/20 0.52
HRH4 Q9H3N8 1/20 0.52
ALDH1A1 P00352 4/20 0.47
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47
POLB P06746 1/20 0.47
DRD2 P14416 2/20 0.47
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7961432 0.86 HPGD (0.54) HPGDSMN1; SMN2HRH3CHRM2CHRM1
SCHEMBL7961036 0.85 HSD11B1 (0.56) HPGDSMN1; SMN2HRH3ALDH1A1LMNA
SCHEMBL7977465 0.82 TP53 (0.49) POLBGAAL3MBTL1
Hydrochloric Acid SCHEMBL7974459 0.81 SMN1; SMN2 (0.50) HPGDSMN1; SMN2HRH3DRD4LMNA
Hydrochloric Acid SCHEMBL7977435 0.81 L3MBTL3 (0.50) HPGDSMN1; SMN2ALDH1A1KMT2AMEN1
SCHEMBL7971240 0.79 GPR119 (0.55) HPGDSMN1; SMN2ALDH1A1DRD2GAA
SCHEMBL7974717 0.79 PKM (0.48) SMN1; SMN2ALDH1A1POLBL3MBTL1
SCHEMBL7977603 0.79 L3MBTL1 (0.47) HRH3ALDH1A1MAPTGAAKMT2A
SCHEMBL7974636 0.77 ITGB3 (0.42) HRH3CHRM2SLC6A4L3MBTL1
SCHEMBL7971121 0.76 GPR119 (0.51) HPGDSMN1; SMN2ALDH1A1DRD2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6326369-B1 ALZHEIMER'S DISEASE TAKEDA CHEMICALS INDUSTRIES, LTD. (JP) 2001-12-04 US disclosed
EP-0968164-A1 BICYCLIC QUINONE COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 2000-01-05 EP disclosed
WO-1998033758-A1 BICYCLIC QUINONE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-08-06 WO disclosed