Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988184 | 0.91 | MET (0.42) | SMN1; SMN2CYP11B1CYP11B2LMNAHTT | |
| SCHEMBL7974646 | 0.91 | MAPK14 (0.47) | SMN1; SMN2CYP11B1CYP11B2MAPK14MET | |
| SCHEMBL7974309 | 0.88 | CYP11B1 (0.45) | SMN1; SMN2CYP11B1CYP11B2LMNAHTT | |
| SCHEMBL7984199 | 0.88 | NR1H4 (0.44) | SMN1; SMN2CYP11B1CYP11B2MAPK14MET | |
| SCHEMBL7984878 | 0.84 | MAPK14 (0.42) | SMN1; SMN2LMNAHTTMAPK14MET | |
| SCHEMBL7973917 | 0.84 | LMNA (0.40) | LMNAMAPK14METHDAC1HDAC6 | |
| SCHEMBL7984717 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP11B1CYP11B2LMNAHTT | |
| SCHEMBL7988454 | 0.83 | MAPK14 (0.41) | CYP11B1CYP11B2MAPK14METGAA | |
| SCHEMBL7991532 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2CYP11B1CYP11B2LMNAHTT | |
| SCHEMBL7985165 | 0.82 | MET (0.47) | SMN1; SMN2CYP11B1CYP11B2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |