Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.44 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CCKAR | P32238 | 2/20 | 0.34 |
| ▸ | CCKBR | P32239 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974060 | 0.88 | SMN1; SMN2 (0.41) | HDAC1HDAC6MAPK14METCYP11B1 | |
| SCHEMBL7988184 | 0.88 | MET (0.42) | HDAC1HDAC6MAPK14METCYP11B1 | |
| SCHEMBL7974646 | 0.88 | MAPK14 (0.47) | HDAC1HDAC6MAPK14METCYP11B1 | |
| SCHEMBL7974490 | 0.85 | NR1H4 (0.47) | NR1H4ABCC8KCNJ11TP53CYP11B1 | |
| SCHEMBL7991658 | 0.84 | ABCC8 (0.42) | NR1H4ABCC8KCNJ11HDAC6HPGD | |
| SCHEMBL7987361 | 0.83 | MET (0.45) | NR1H4ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7992267 | 0.82 | ICMT (0.44) | NR1H4ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7974309 | 0.81 | CYP11B1 (0.45) | MAPK14METTP53CYP11B1CYP11B2 | |
| SCHEMBL7984878 | 0.81 | MAPK14 (0.42) | MAPK14METMAPTGAASMN1; SMN2 | |
| SCHEMBL7973917 | 0.81 | LMNA (0.40) | HDAC1HDAC6MAPK14METTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |