Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988454 | 0.89 | MAPK14 (0.41) | CYP11B1CYP11B2MAPK14METGAA | |
| SCHEMBL7974060 | 0.88 | SMN1; SMN2 (0.41) | CYP11B1CYP11B2ALDH1A1HPGDMAPK14 | |
| SCHEMBL7974646 | 0.88 | MAPK14 (0.47) | CYP11B1CYP11B2ALDH1A1TSHRHPGD | |
| SCHEMBL7984878 | 0.88 | MAPK14 (0.42) | MAPK14SMN1; SMN2METLMNAHTT | |
| SCHEMBL7985870 | 0.87 | GAA (0.50) | ALDH1A1TSHRHPGDMAPK14GAA | |
| SCHEMBL7974268 | 0.85 | CYP11B1 (0.48) | CYP11B1CYP11B2ALDH1A1TSHRHPGD | |
| SCHEMBL7991788 | 0.84 | CYP11B1 (0.46) | CYP11B1CYP11B2ALDH1A1TSHRHPGD | |
| SCHEMBL7988567 | 0.84 | HPGD (0.44) | CYP11B1CYP11B2ALDH1A1TSHRHPGD | |
| SCHEMBL7988184 | 0.84 | MET (0.42) | CYP11B1CYP11B2ALDH1A1TSHRHPGD | |
| SCHEMBL7988958 | 0.83 | ALDH1A1 (0.42) | CYP11B1CYP11B2ALDH1A1TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |