Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.34 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.34 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988794 | 0.93 | NR1H4 (0.40) | BRD4MCL1PAX8KAT8NR1H4 | |
| SCHEMBL7985478 | 0.90 | PAX8 (0.45) | GAAMCL1PAX8HPGDHTR2C | |
| SCHEMBL7974152 | 0.83 | HPGD (0.47) | BRD4GAAMCL1PAX8HPGD | |
| SCHEMBL7984761 | 0.82 | CYP17A1 (0.42) | BRD4GAAHPGDADORA3 | |
| SCHEMBL7984728 | 0.82 | NR1H4 (0.41) | PAX8KAT8ALDH1A1NR1H4 | |
| SCHEMBL7985457 | 0.78 | HTR2C (0.46) | GAAMCL1HPGDHTR2CSLC6A4 | |
| SCHEMBL7974157 | 0.78 | BRD4 (0.44) | BRD4MCL1PAX8HPGDHTR2C | |
| SCHEMBL7974177 | 0.77 | MCL1 (0.41) | GAAMCL1HPGDHTR2CSLC6A4 | |
| SCHEMBL7988594 | 0.77 | TP53 (0.44) | GAAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL7985336 | 0.77 | PIK3CA (0.42) | GAAHPGDALDH1A1SMN1; SMN2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |