Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977544 | 0.92 | LMNA (0.57) | MAPTNPC1SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL7975323 | 0.89 | SMN1; SMN2 (0.51) | MAPTNPC1SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL7975349 | 0.83 | CYP1A2 (0.51) | NPC1RAB9ALMNAGAA | |
| SCHEMBL7977571 | 0.83 | NPC1 (0.53) | NPC1SMN1; SMN2RAB9AKMT2ALMNA | |
| SCHEMBL7980306 | 0.82 | NPSR1 (0.49) | NPC1RAB9AGAA | |
| SCHEMBL7980389 | 0.81 | NPC1 (0.49) | MAPTNPC1RAB9AKMT2ALMNA | |
| SCHEMBL7977633 | 0.81 | SMN1; SMN2 (0.56) | MAPTNPC1SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL7974413 | 0.81 | SMN1; SMN2 (0.59) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL7980374 | 0.81 | SMN1; SMN2 (0.52) | MAPTNPC1SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL7977564 | 0.80 | POLB (0.50) | NPC1SMN1; SMN2RAB9AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |