Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.43 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.43 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.43 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.43 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.43 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.43 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.43 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.43 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.43 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.43 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.43 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.43 |
| ▸ | PSMB3 | P49720 | 3/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9394054 | 0.87 | FAAH (0.41) | POLBGAAFPR2PSMB5PSMB11 | |
| SCHEMBL7962534 | 0.86 | KMT2A (0.44) | FPR2PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL7962547 | 0.79 | ITGB3 (0.55) | ATM | |
| SCHEMBL9394451 | 0.78 | KMT2A (0.48) | POLBNAMPT | |
| SCHEMBL9392962 | 0.76 | POLB (0.48) | POLBHTT | |
| SCHEMBL9394724 | 0.76 | KMT2A (0.39) | POLBGAASMN1; SMN2 | |
| SCHEMBL7389409 | 0.76 | KMT2A (0.47) | POLBNAMPT | |
| SCHEMBL7382928 | 0.74 | GAA (0.48) | POLBGAALMNAHTTNAMPT | |
| SCHEMBL7962515 | 0.72 | ITGB3 (0.49) | POLBGAAATMRAB9ANPC1 | |
| SCHEMBL7380058 | 0.72 | CTSG (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268380-B1 | E.G., ETHYL BETA-((N-3(((4(AMINOIMINOMETHYL)PHENYL)AMINO)CARBONYL)PIPERIDY LCARBONYL)AMINO)-3-PYRIDINEPROPANOATE | G. D. SEARLE & CO. | 2001-07-31 | — | — | US | disclosed |
| WO-1994019341-A1 | UREA DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1994-09-01 | — | — | WO | disclosed |