Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979433 | 0.90 | EDNRB (0.38) | PLK1MAPTIRAK4POLBCNR2 | |
| SCHEMBL7979128 | 0.83 | MAPT (0.41) | PLK1MAPTIRAK4POLBCNR2 | |
| SCHEMBL7997022 | 0.82 | MAPT (0.41) | PLK1MAPTIRAK4POLBCNR2 | |
| SCHEMBL7997001 | 0.81 | EDNRA (0.51) | IRAK4EDNRBEDNRA | |
| SCHEMBL7996803 | 0.78 | EDNRA (0.48) | MAPTIRAK4POLBEDNRBEDNRA | |
| SCHEMBL7979090 | 0.77 | ALDH1A1 (0.42) | MAPTIRAK4POLBCNR2HPGD | |
| SCHEMBL7991613 | 0.76 | GPR84 (0.40) | PLK1MAPTIRAK4POLBEDNRB | |
| SCHEMBL7993983 | 0.75 | PIK3CA (0.42) | MAPTIRAK4POLBKMT2ASMN1; SMN2 | |
| SCHEMBL7993551 | 0.75 | EDNRA (0.49) | IRAK4POLBEDNRBEDNRA | |
| SCHEMBL7997147 | 0.74 | GPR84 (0.40) | MAPTIRAK4POLBKMT2AGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |