Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979093 | 0.90 | ALDH1A1 (0.47) | ALDH1A1HPGDMAPTPTK2EDNRB | |
| SCHEMBL7993983 | 0.87 | PIK3CA (0.42) | ALDH1A1MAPTIRAK4PTK2EDNRB | |
| SCHEMBL7997001 | 0.82 | EDNRA (0.51) | IRAK4EDNRBEDNRA | |
| SCHEMBL7996803 | 0.80 | EDNRA (0.48) | MAPTIRAK4EDNRBEDNRAPOLB | |
| SCHEMBL7979128 | 0.78 | MAPT (0.41) | ALDH1A1HPGDMAPTIRAK4EDNRB | |
| SCHEMBL7993990 | 0.78 | RAB9A (0.44) | ALDH1A1HPGDMAPTPTK2EDNRB | |
| SCHEMBL7991472 | 0.78 | EDNRA (0.61) | EDNRBEDNRA | |
| SCHEMBL7991613 | 0.78 | GPR84 (0.40) | ALDH1A1MAPTIRAK4EDNRBEDNRA | |
| SCHEMBL7997022 | 0.77 | MAPT (0.41) | ALDH1A1MAPTIRAK4PTK2EDNRB | |
| SCHEMBL7979428 | 0.77 | PLK1 (0.42) | ALDH1A1HPGDMAPTIRAK4EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |