Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993990 | 0.91 | RAB9A (0.44) | PIK3CAMTORPTK2RAB9AHSD17B10 | |
| SCHEMBL7979090 | 0.87 | ALDH1A1 (0.42) | PTK2RAB9AKDM4EHIF1AEDNRB | |
| SCHEMBL7979093 | 0.79 | ALDH1A1 (0.47) | PTK2EDNRBEDNRAMAPTALDH1A1 | |
| SCHEMBL7997001 | 0.78 | EDNRA (0.51) | EDNRBEDNRAIRAK4 | |
| SCHEMBL7979128 | 0.77 | MAPT (0.41) | KDM4ELMNAEDNRBEDNRAMAPT | |
| SCHEMBL7997022 | 0.77 | MAPT (0.41) | PTK2EDNRBEDNRAMAPTIRAK4 | |
| SCHEMBL7996803 | 0.76 | EDNRA (0.48) | EDNRBEDNRAMAPTIRAK4POLB | |
| SCHEMBL7991613 | 0.75 | GPR84 (0.40) | EDNRBEDNRAMAPTIRAK4ALDH1A1 | |
| SCHEMBL7997147 | 0.75 | GPR84 (0.40) | MAPTIRAK4MEN1KMT2APOLB | |
| SCHEMBL7979428 | 0.75 | PLK1 (0.42) | KDM4EEDNRBEDNRAMAPTIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |