Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | UTRN | P46939 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744196 | 0.84 | KDR (0.54) | KDRFLT1FLT4ALOX15NPC1 | |
| SCHEMBL7979682 | 0.83 | KDR (0.46) | KDRFLT1FLT4UTRNALOX15 | |
| SCHEMBL7980768 | 0.81 | KDR (0.45) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7986670 | 0.80 | KDR (0.50) | KDRFLT1FLT4ALOX15NPC1 | |
| SCHEMBL7979899 | 0.79 | KDR (0.52) | KDRFLT1FLT4UTRNALOX15 | |
| SCHEMBL7979692 | 0.78 | KDR (0.54) | KDRFLT1FLT4UTRNALOX15 | |
| SCHEMBL7982616 | 0.78 | KDR (0.56) | KDRFLT1FLT4UTRNALOX15 | |
| SCHEMBL7981618 | 0.78 | KDR (0.44) | KDRFLT1FLT4ALOX15CLK4 | |
| SCHEMBL7744746 | 0.77 | HPN (0.45) | KDRFLT1FLT4MAPTTP53 | |
| SCHEMBL7744779 | 0.76 | KDR (0.43) | KDRFLT1FLT4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |