Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 2/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749884 | 0.82 | LMNA (0.50) | PTGS2ESR1ESR2KDM4EMEN1 | |
| SCHEMBL4395024 | 0.82 | MAOA (0.66) | KDM4EMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL1445004 | 0.77 | MAOA (0.69) | PTGS2KDM4EMEN1KMT2ACYP3A4 | |
| SCHEMBL29633014 | 0.77 | MAOA (0.69) | PTGS2KDM4EMEN1KMT2ACYP3A4 | |
| SCHEMBL7984298 | 0.77 | ESR2 (0.75) | PTGS2ESR1ESR2KDM4ECYP3A4 | |
| SCHEMBL1179868 | 0.76 | MAOA (0.52) | PTGS2KDM4EMEN1KMT2ACYP3A4 | |
| SCHEMBL30900701 | 0.75 | L3MBTL1 (0.62) | KDM4EMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL3881176 | 0.74 | PTGS2 (0.74) | PTGS2KDM4EMEN1KMT2ACYP3A4 | |
| SCHEMBL17384091 | 0.74 | TDP1 (0.67) | KDM4EMEN1KMT2ACYP3A4MAPT | |
| SCHEMBL29872 | 0.74 | KDM4E (0.69) | KDM4EMEN1KMT2ACYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |