SCHEMBL798266

SCHEMBL798266

Fc1ccc(-c2cc3cnc(NCc4ccccc4)nc3s2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 1/20 0.47
TP53 P04637 3/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
EGFR P00533 1/20 0.45
GAA P10253 3/20 0.44
KDM4E B2RXH2 3/20 0.44
ALDH1A1 P00352 3/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
MAPK1 P28482 1/20 0.44
HSD17B10 Q99714 1/20 0.44
KCNH3 Q9ULD8 2/20 0.44
LMNA P02545 1/20 0.43
KIT P10721 1/20 0.41
ADORA2A P29274 2/20 0.41
MAPT P10636 1/20 0.41
MAPK14 Q16539 2/20 0.41
RPS6KB1 P23443 2/20 0.41
FGFR1 P11362 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL794138 0.77 ADORA1 (0.47) SMN1; SMN2KDM4EALDH1A1LMNAADORA2A
SCHEMBL653610 0.73 APP (0.58) SMN1; SMN2EGFRLMNAMAPTFGFR1
SCHEMBL3785754 0.69 PTGS2 (0.46) PTGS2TP53SMN1; SMN2GAAKDM4E
SCHEMBL3783305 0.68 MEN1 (0.49) PTGS2TP53SMN1; SMN2GAAKDM4E
SCHEMBL7215223 0.68 PTGS2 (0.71) PTGS2TP53GAAKDM4EALDH1A1
SCHEMBL38658460 0.67 FGFR1 (0.43) SMN1; SMN2KDM4EALDH1A1HSD17B10LMNA
SCHEMBL14006036 0.66 ADORA3 (0.58) SMN1; SMN2GAAKDM4EALDH1A1L3MBTL1
SCHEMBL9345255 0.66 LMNA (0.80) TP53SMN1; SMN2GAAL3MBTL1KCNH3
SCHEMBL655474 0.66 SIRT5 (0.58) GAAKDM4EALDH1A1L3MBTL1MAPK1
SCHEMBL18341986 0.66 CYP2A6 (0.46) KDM4EMAPTMAPK14FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2616077-A1 ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) 2013-07-24 EP disclosed
WO-2012035423-A1 ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) 2012-03-22 WO disclosed
EP-2405973-A2 THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) 2012-01-18 EP disclosed
WO-2011147753-A1 ANTIVIRAL ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) 2011-12-01 WO disclosed