Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13876006 | 0.80 | GCK (0.39) | NR1H3ADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL16168677 | 0.78 | PTGS1 (0.45) | NR1H3SMN1; SMN2KDM4EADRA2AADRA2B | |
| SCHEMBL19002591 | 0.75 | ALDH1A1 (0.47) | HTTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL9792783 | 0.73 | UHRF1 (0.54) | KDM4EMEN1KMT2ACRHR1DRD1 | |
| SCHEMBL21251081 | 0.71 | CCR1 (0.50) | SMN1; SMN2KDM4ETYK2JAK2JAK1 | |
| SCHEMBL8285845 | 0.71 | LOXL2 (0.57) | HTTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL27272064 | 0.70 | ALOX5AP (0.41) | HTTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL28636296 | 0.69 | CRHR1 (0.36) | SMN1; SMN2KCNH2CRHR1ALDH1A1DRD1 | |
| SCHEMBL21241035 | 0.69 | MEN1 (0.48) | NR1H3HTTLMNAMEN1KMT2A | |
| SCHEMBL10022356 | 0.69 | ADRA2A (0.40) | NR1H3HTTSMN1; SMN2ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010005783-A1 | PYRROLIDINYL AND PIPERIDINYL COMPOUNDS USEFUL AS NHE-1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-14 | — | — | WO | disclosed |