Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | ADH5 | P11766 | 5/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5735726 | 0.82 | ADH5 (0.47) | ADH5TBXAS1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5736507 | 0.79 | FFAR1 (0.44) | TBXAS1 | |
| SCHEMBL5738924 | 0.77 | LMNA (0.49) | PDE4APDE4BPDE4CPDE4DTBXAS1 | |
| SCHEMBL6427628 | 0.76 | TDP1 (0.38) | LMNAALDH1A1KMT2AAAK1CYP3A4 | |
| SCHEMBL6427152 | 0.74 | TBXAS1 (0.35) | PDE4APDE4BPDE4CPDE4DADH5 | |
| SCHEMBL7984143 | 0.74 | TBXAS1 (0.50) | TBXAS1 | |
| SCHEMBL5800531 | 0.72 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DADH5 | |
| SCHEMBL15174944 | 0.70 | CSNK2A1 (0.45) | PDE4APDE4BPDE4CPDE4DADH5 | |
| SCHEMBL5735868 | 0.69 | ADH5 (0.38) | ADH5DHODHCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1893489 | 0.69 | MAOB (0.44) | PDE4APDE4BPDE4CPDE4DADH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303785-B1 | SUBSTITUTED N-CYCLOPROPYLTETRAHYDROISOQUINOLINES | ALLERGAN SALES, INC. | 2001-10-16 | — | — | US | disclosed |