Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.40 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984751 | 0.90 | NTRK1 (0.46) | NPC1RAB9ALMNAHPGDHSD17B13 | |
| SCHEMBL7974555 | 0.85 | HDAC1 (0.45) | HDAC1HDAC2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7987920 | 0.83 | TP53 (0.47) | SMN1; SMN2NPC1RAB9ALMNAGAA | |
| SCHEMBL7984889 | 0.81 | NPC1 (0.46) | SMN1; SMN2NPC1RAB9AGAAHPGD | |
| SCHEMBL7988677 | 0.81 | SMN1; SMN2 (0.51) | HDAC3HDAC1HDAC2SMN1; SMN2NPC1 | |
| SCHEMBL7987938 | 0.79 | KDM4E (0.44) | RAB9ALMNAL3MBTL1ALDH1A1ADORA3 | |
| SCHEMBL7984257 | 0.78 | RAB9A (0.48) | SMN1; SMN2NPC1RAB9ALMNASIRT2 | |
| SCHEMBL7992620 | 0.78 | NPC1 (0.53) | SMN1; SMN2NPC1RAB9ASIRT2L3MBTL1 | |
| SCHEMBL7985108 | 0.78 | EPHX2 (0.52) | HDAC3HDAC1HDAC2SMN1; SMN2NPC1 | |
| SCHEMBL7985416 | 0.77 | LMNA (0.50) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |