Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 4/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7973917 | 0.87 | LMNA (0.40) | ALDH1A1ADORA2AADORA1LMNAPOLB | |
| SCHEMBL7987222 | 0.85 | PDE4A (0.49) | NPC1RAB9AALDH1A1LMNAPOLB | |
| SCHEMBL7974053 | 0.84 | MET (0.44) | TDP1KDM4EFFAR1 | |
| SCHEMBL7991417 | 0.84 | PDE4A (0.42) | NPC1RAB9AALDH1A1KDM4AKDM5A | |
| SCHEMBL7985492 | 0.83 | SMN1; SMN2 (0.42) | NPC1RAB9AALDH1A1TP53TDP1 | |
| SCHEMBL7986754 | 0.83 | PDE4A (0.45) | NPC1RAB9AALDH1A1ADORA2AADORA1 | |
| SCHEMBL7974007 | 0.81 | KDM4C (0.41) | NPC1RAB9AALDH1A1ADORA2AADORA1 | |
| SCHEMBL7985118 | 0.81 | ADRB2 (0.41) | NPC1RAB9AALDH1A1HTTLMNA | |
| SCHEMBL7984681 | 0.80 | PDE4A (0.41) | ALDH1A1ADORA2AADORA1LMNAPOLB | |
| SCHEMBL7988749 | 0.80 | PDE4A (0.41) | ALDH1A1LMNAPOLBTP53PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |