Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 4/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4926929 | 0.91 | NPC1 (0.45) | NPC1RAB9AHTR2CHTR6F2 | |
| SCHEMBL4926920 | 0.78 | ALDH1A1 (0.47) | NPC1RAB9AHTR2CHTR6F2 | |
| SCHEMBL7987856 | 0.78 | MMP9 (0.49) | F2PRSS1PRSS2PRSS3MMP2 | |
| SCHEMBL1770435 | 0.74 | MMP13 (0.58) | MMP2MMP13 | |
| SCHEMBL1770344 | 0.74 | MMP13 (0.58) | MMP2MMP13 | |
| SCHEMBL20021986 | 0.73 | HTR2C (0.56) | NPC1RAB9AHTR2CHTR6LMNA | |
| SCHEMBL4927454 | 0.71 | F2 (0.49) | NPC1RAB9AF2PRSS1PRSS2 | |
| SCHEMBL14294227 | 0.71 | NPC1 (0.56) | NPC1RAB9AHTR2CHTR6LMNA | |
| SCHEMBL7371173 | 0.70 | SLC1A3 (0.59) | F2PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL6825950 | 0.70 | NPC1 (0.52) | NPC1RAB9AF2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242467-B1 | (N-HYDROXYAMIDO)-ALKYLSULFONAMIDE DERIVATIVES; INHIBITORS OF TUMOR NECROSIS FACTOR AND CD23 ANTIGEN; AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-05 | — | — | US | claimed |