Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 9/20 | 0.49 |
| ▸ | MMP2 | P08253 | 8/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 8/20 | 0.47 |
| ▸ | MMP8 | P22894 | 7/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386007 | 0.86 | ADAMTS4 (0.51) | MMP9MMP2CA1CA2CA9 | |
| SCHEMBL7987098 | 0.78 | NPC1 (0.46) | MMP2MMP13PKMF2PRSS1 | |
| SCHEMBL6510024 | 0.75 | ADAMTS4 (0.68) | MMP9MMP2CA1CA2CA9 | |
| SCHEMBL4916977 | 0.74 | ALDH1A1 (0.41) | CA1CA2CA9ALDH1A1KEAP1 | |
| SCHEMBL6502002 | 0.72 | MMP13 (0.67) | MMP9MMP2CA1CA2CA9 | |
| SCHEMBL7451136 | 0.71 | MMP2 (0.57) | MMP9MMP2CA1CA2CA9 | |
| SCHEMBL6465700 | 0.71 | KEAP1 (0.50) | MMP9MMP2CA1CA2CA9 | |
| SCHEMBL3868587 | 0.70 | LMNA (0.55) | MMP9MMP2MMP13MMP8MMP1 | |
| SCHEMBL6498314 | 0.70 | ADAMTS4 (0.47) | MMP9MMP2CA1CA2CA9 | |
| SCHEMBL14350865 | 0.70 | PKM (0.52) | MMP9MMP2CA1CA2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242467-B1 | (N-HYDROXYAMIDO)-ALKYLSULFONAMIDE DERIVATIVES; INHIBITORS OF TUMOR NECROSIS FACTOR AND CD23 ANTIGEN; AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-05 | — | — | US | claimed |
| US-6242467-B1 | (N-HYDROXYAMIDO)-ALKYLSULFONAMIDE DERIVATIVES; INHIBITORS OF TUMOR NECROSIS FACTOR AND CD23 ANTIGEN; AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-05 | — | — | US | disclosed |
| EP-0973732-A2 | ARYL- OR HETEROARYLSULFONAMIDE SUBSTITUTED HYDROXAMIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SMITHKLINE BEECHAM PLC (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998042659-A2 | ARYL- OR HETEROARYLSULFONAMIDE SUBSTITUTED HYDROXAMIC ACID DERIVATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-01 | — | — | WO | disclosed |