Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 4/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990330 | 0.84 | OGA (0.43) | OGAEDNRAHPGDKDM4EALDH1A1 | |
| SCHEMBL8807232 | 0.76 | EDNRA (0.44) | OGAEDNRAHPGDKDM4EALDH1A1 | |
| SCHEMBL8789026 | 0.72 | RAB9A (0.55) | OGAEDNRAHPGDKDM4EALDH1A1 | |
| SCHEMBL7976015 | 0.71 | EDNRA (0.44) | EDNRAHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL7975989 | 0.70 | EDNRA (0.41) | EDNRAHPGDALDH1A1SCD5HTT | |
| SCHEMBL7987498 | 0.68 | RAB9A (0.48) | OGAHPGDKDM4EALDH1A1NPC1 | |
| SCHEMBL6138702 | 0.68 | RAB9A (0.56) | OGAEDNRAHPGDKDM4EALDH1A1 | |
| SCHEMBL12053329 | 0.67 | CYP3A4 (0.55) | OGAHPGDNPC1RAB9AHTT | |
| SCHEMBL7359562 | 0.67 | EDNRA (0.54) | EDNRAHPGDKDM4ENPC1RAB9A | |
| SCHEMBL5849380 | 0.67 | DGAT2 (0.37) | ALDH1A1NPC1RAB9AHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |