Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 4/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987355 | 0.84 | OGA (0.43) | OGAEDNRASCD5HPGDNPC1 | |
| SCHEMBL7990492 | 0.79 | SIRT2 (0.44) | OGAEDNRAHPGD | |
| SCHEMBL8810776 | 0.76 | EDNRA (0.44) | OGAEDNRAHPGDNPC1RAB9A | |
| SCHEMBL2800705 | 0.74 | SLC6A3 (0.37) | — | |
| SCHEMBL6975784 | 0.73 | RAB9A (0.51) | OGAEDNRAHPGDNPC1RAB9A | |
| SCHEMBL7987522 | 0.73 | EDNRA (0.47) | EDNRAHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL7987573 | 0.73 | EDNRA (0.44) | OGAEDNRASCD5HPGDNPC1 | |
| SCHEMBL7986399 | 0.71 | EDNRA (0.42) | EDNRASCD5KDM4EALDH1A1CYP1A2 | |
| SCHEMBL7359562 | 0.71 | EDNRA (0.54) | EDNRAHPGDNPC1RAB9AKDM4E | |
| SCHEMBL7986471 | 0.71 | EDNRA (0.54) | EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |