Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CNOT7 | Q9UIV1 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985288 | 0.93 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2CNOT7TSHR | |
| SCHEMBL7984242 | 0.86 | CNOT7 (0.45) | CNOT7TSHRKDM4EPOLBLMNA | |
| SCHEMBL7985492 | 0.86 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2CNOT7KDM4E | |
| SCHEMBL7991652 | 0.84 | CNOT7 (0.42) | CNOT7TSHRKDM4EPOLBLMNA | |
| SCHEMBL7984465 | 0.83 | CNOT7 (0.41) | CNOT7TSHRFAAHKDM4EPOLB | |
| SCHEMBL7974043 | 0.81 | GBA1 (0.43) | NPC1RAB9ACNOT7TSHRKDM4E | |
| SCHEMBL7985603 | 0.81 | CNOT7 (0.41) | CNOT7TSHRFAAHKDM4EPOLB | |
| SCHEMBL7984490 | 0.81 | CNOT7 (0.41) | CNOT7TSHRFAAHKDM4EPOLB | |
| SCHEMBL7992303 | 0.80 | CNOT7 (0.40) | CNOT7TSHRFAAHKDM4EPOLB | |
| SCHEMBL7986355 | 0.78 | SIGMAR1 (0.42) | CNOT7TSHRFAAHKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |