Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | METAP1 | P53582 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CNOT7 | Q9UIV1 | 6/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988802 | 0.93 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2METAP1TDP1 | |
| SCHEMBL7985492 | 0.88 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2METAP1TDP1 | |
| SCHEMBL7974615 | 0.85 | ADORA2A (0.44) | HTTCNOT7ALDH1A1 | |
| SCHEMBL7991678 | 0.83 | HTT (0.40) | RAB9ASMN1; SMN2KMT2AHTTCNOT7 | |
| SCHEMBL7974276 | 0.82 | HTT (0.39) | HTTCNOT7ALDH1A1 | |
| SCHEMBL7986327 | 0.81 | NPC1 (0.43) | NPC1RAB9AL3MBTL1KMT2AHTT | |
| SCHEMBL7973871 | 0.80 | ADORA3 (0.40) | HTTCNOT7ALDH1A1 | |
| SCHEMBL7991532 | 0.79 | SMN1; SMN2 (0.43) | NPC1RAB9ASMN1; SMN2METAP1TDP1 | |
| SCHEMBL7974053 | 0.79 | MET (0.44) | TDP1MCL1KDM4EF2F12 | |
| SCHEMBL7984406 | 0.79 | CASR (0.43) | HTTCNOT7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |