Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | USP19 | O94966 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974276 | 0.93 | HTT (0.39) | CNOT7POLBMAPK1MAPK14MAPT | |
| SCHEMBL7974646 | 0.86 | MAPK14 (0.47) | CNOT7TSHRPOLBMAPK1MAPK14 | |
| SCHEMBL7985446 | 0.86 | GBA1 (0.41) | CNOT7TSHRLMNAMAPK14MAPT | |
| SCHEMBL7984242 | 0.85 | CNOT7 (0.45) | CNOT7TSHRPOLBMAPK1KDM4E | |
| SCHEMBL7985603 | 0.84 | CNOT7 (0.41) | CNOT7TSHRPOLBMAPK1KDM4E | |
| SCHEMBL7988802 | 0.83 | NPC1 (0.44) | CNOT7TSHRPOLBMAPK1KDM4E | |
| SCHEMBL7974291 | 0.82 | CNOT7 (0.39) | CNOT7TSHRPOLBMAPK1KDM4E | |
| SCHEMBL7991652 | 0.81 | CNOT7 (0.42) | CNOT7TSHRPOLBMAPK1KDM4E | |
| SCHEMBL7984490 | 0.80 | CNOT7 (0.41) | CNOT7TSHRPOLBMAPK1KDM4E | |
| SCHEMBL7988184 | 0.80 | MET (0.42) | TSHRMAPK1KDM4ELMNAMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |