Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 6/20 | 0.43 |
| ▸ | APP | P05067 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 3/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986540 | 0.78 | POLB (0.44) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL22670400 | 0.75 | KMT2A (0.60) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL28030315 | 0.71 | XDH (0.51) | MAPTRAB9AGAAMEN1KMT2A | |
| SCHEMBL7989137 | 0.71 | POLB (0.41) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL7989098 | 0.70 | CA1 (0.57) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL28305325 | 0.70 | XDH (0.54) | MAPTRAB9AMEN1KMT2ALMNA | |
| SCHEMBL22276768 | 0.67 | SMN1; SMN2 (0.56) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL13078874 | 0.66 | METAP2 (0.32) | NPC1RAB9ASMN1; SMN2 | |
| Acetic Acid SCHEMBL27872989 | 0.66 | GAA (0.41) | MAPTKDM4EGAAMEN1KMT2A | |
| SCHEMBL7974687 | 0.66 | ROCK2 (0.47) | POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271373-B1 | PYRIDINE DERIVATIVE FORMED BY REACTING A PYRAZINE DERIVATIVE WITH FECL3 AND ACETIC ACID | VIROPHARMA INCORPORATED | 2001-08-07 | — | — | US | claimed |