Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.37 |
| ▸ | MEN1 | O00255 | 7/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 3/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974687 | 0.78 | ROCK2 (0.47) | POLBCYP3A4 | |
| SCHEMBL7986540 | 0.73 | POLB (0.44) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL7988922 | 0.71 | POLB (0.44) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL9717736 | 0.70 | L3MBTL1 (0.40) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL7975778 | 0.70 | POLB (0.58) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL7991950 | 0.69 | ALDH1A1 (0.33) | MAPTKDM4EGAAKMT2AMEN1 | |
| SCHEMBL9812745 | 0.69 | POLB (0.43) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL3726621 | 0.68 | SLC2A1 (0.41) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL7989098 | 0.68 | CA1 (0.57) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL15304484 | 0.67 | MAPT (0.69) | POLBMAPTKDM4EGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271373-B1 | PYRIDINE DERIVATIVE FORMED BY REACTING A PYRAZINE DERIVATIVE WITH FECL3 AND ACETIC ACID | VIROPHARMA INCORPORATED | 2001-08-07 | — | — | US | claimed |
| US-6271373-B1 | PYRIDINE DERIVATIVE FORMED BY REACTING A PYRAZINE DERIVATIVE WITH FECL3 AND ACETIC ACID | VIROPHARMA INCORPORATED | 2001-08-07 | — | — | US | disclosed |
| US-6180628-B1 | PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES AND THEIR USE IN TREATING INFLUENZA INFECTION AND OTHER VIRAL DISEASES | VIROPHARMA INCORPORATED | 2001-01-30 | — | — | US | disclosed |
| EP-0920419-A4 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA | VIROPHARMA INC (US) | 1999-10-06 | — | — | EP | disclosed |
| US-5935957-A | PYRIDAZINE DERIVATIVES | VIROPHARMA INCORPORATED (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0920419-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA | Viropharma Incorporated (US) | 1999-06-09 | — | — | EP | disclosed |
| US-5821243-A | 3,4,5-TRIOXO-2H,3H,4H,5H-PYRIDAZINES; TRANSCRIPTASE INHIBITORS; NONTOXIC | VIROPHARMA INCORPORATED (US) | 1998-10-13 | — | — | US | disclosed |
| WO-1998003487-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA | VIROPHARMA INCORPORATED (US) | 1998-01-29 | — | — | WO | disclosed |