Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 3/20 | 0.52 |
| ▸ | MME | P08473 | 2/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 4/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | CCKBR | P32239 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989539 | 1.00 | MMP9 (0.52) | MMP9MMEACECPA1ACE2 | |
| SCHEMBL7986859 | 0.86 | MMP9 (0.45) | MMP9MMEACECPA1ACE2 | |
| SCHEMBL7976201 | 0.83 | TACR1 (0.59) | MMP9ACEMMP8MMP14TACR1 | |
| SCHEMBL7976198 | 0.83 | TACR1 (0.59) | MMP9ACEMMP8MMP14TACR1 | |
| SCHEMBL7990061 | 0.83 | NLN (0.49) | MMP9CTNNB1METAP2KDM4EMEN1 | |
| SCHEMBL7993920 | 0.79 | ALDH1A1 (0.39) | ACETACR1MEN1ALDH1A1MAPT | |
| SCHEMBL7993921 | 0.79 | ALDH1A1 (0.39) | ACETACR1MEN1ALDH1A1MAPT | |
| SCHEMBL7988005 | 0.79 | TACR1 (0.40) | TACR1 | |
| SCHEMBL7988007 | 0.75 | RAB9A (0.39) | MMP9MMP8MMP14MEN1KMT2A | |
| SCHEMBL4653589 | 0.74 | FAAH (0.50) | MMP9MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306865-B1 | SYNTHASE INHIBITORS AND ANTITUMOR AGENTS | GLAXO WELLCOME INC. | 2001-10-23 | — | — | US | disclosed |