Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | APLNR | P35414 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.65 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29468637 | 0.87 | RAB9A (0.72) | MAPTALDH1A1MAPK1APLNRL3MBTL1 | |
| SCHEMBL19976901 | 0.83 | GAA (0.59) | MAPTALDH1A1MAPK1APLNRL3MBTL1 | |
| SCHEMBL12666618 | 0.82 | MAPK1 (0.66) | MAPTALDH1A1MAPK1APLNRTSHR | |
| SCHEMBL19476108 | 0.81 | SMN1; SMN2 (0.61) | MAPTALDH1A1L3MBTL1GPR174SMN1; SMN2 | |
| SCHEMBL7291904 | 0.81 | TSHR (0.74) | MAPTALDH1A1MAPK1APLNRTSHR | |
| SCHEMBL28348976 | 0.81 | MAPK1 (1.00) | MAPTALDH1A1MAPK1APLNRTSHR | |
| SCHEMBL28857621 | 0.80 | GPR174 (0.69) | MAPTALDH1A1MAPK1L3MBTL1GPR174 | |
| SCHEMBL1520408 | 0.80 | KCNMA1 (0.72) | MAPTALDH1A1L3MBTL1GPR174NPC1 | |
| SCHEMBL1520706 | 0.80 | ALDH1A1 (0.61) | MAPTALDH1A1MAPK1L3MBTL1GPR174 | |
| SCHEMBL4717956 | 0.80 | MAPT (0.63) | MAPTALDH1A1MAPK1APLNRTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331637-B1 | N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION | 2001-12-18 | — | — | US | disclosed |