Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | USP1 | O94782 | 1/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26855947 | 0.79 | CYP2E1 (0.42) | CASP6LRRK2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL22040916 | 0.77 | CASP6 (0.39) | CASP6LRRK2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL20102298 | 0.74 | KDM4E (0.44) | CASP6LRRK2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL10094405 | 0.74 | GPR55 (0.46) | LRRK2METBRD4ALOX5APFEN1 | |
| SCHEMBL10094417 | 0.72 | ROCK2 (0.39) | HSP90AA1HSP90AB1MAPK14 | |
| SCHEMBL20232782 | 0.71 | MET (0.38) | CASP6LRRK2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL12427197 | 0.71 | CYP2E1 (0.51) | CASP6LRRK2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL14883263 | 0.70 | USP1 (0.39) | CASP6HRH4USP1MAPK14BRD4 | |
| SCHEMBL10094408 | 0.70 | RPS6KA3 (0.46) | MAPK14 | |
| SCHEMBL23419417 | 0.69 | PTGS1 (0.39) | CYP2A6CYP2C9CYP2C19HSP90AA1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | MTOR, STAT3, SLC14A1 | CASP6 754/4885LRRK2 2392/4885CYP2E1 4733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.