Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994388 | 0.82 | SMN1; SMN2 (0.40) | TP53SMN1; SMN2ALDH1A1HTR7 | |
| SCHEMBL7984361 | 0.81 | SMN1; SMN2 (0.36) | TP53SMN1; SMN2ALDH1A1KDM4ETHRB | |
| SCHEMBL7984069 | 0.81 | SMN1; SMN2 (0.39) | TP53SMN1; SMN2ALDH1A1HTR7 | |
| SCHEMBL7994551 | 0.77 | HDAC1 (0.39) | TP53SMN1; SMN2ALDH1A1THRBLMNA | |
| SCHEMBL7998624 | 0.77 | KMT2A (0.35) | TP53SMN1; SMN2ALDH1A1THRBGAA | |
| SCHEMBL7994472 | 0.76 | HDAC1 (0.39) | ALDH1A1 | |
| SCHEMBL7997629 | 0.74 | LMNA (0.47) | TP53SMN1; SMN2ALDH1A1GAAHPGD | |
| SCHEMBL7975229 | 0.69 | NPC1 (0.51) | SMN1; SMN2ALDH1A1HPGDLMNA | |
| SCHEMBL8580104 | 0.62 | HTR7 (0.46) | HTR7 | |
| SCHEMBL38651331 | 0.61 | RAB9A (0.57) | TP53SMN1; SMN2ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034578-A1 | COMPOUNDS WITH ANTI-HELICOBACTER PYLORI ACTIVITY | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |