Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.47 |
| ▸ | MMP9 | P14780 | 6/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 13/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 11/20 | 0.42 |
| ▸ | MMP13 | P45452 | 8/20 | 0.42 |
| ▸ | MMP14 | P50281 | 4/20 | 0.42 |
| ▸ | MMP3 | P08254 | 3/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | AOC2 | O75106 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991238 | 0.82 | ADAMTS4 (0.44) | MMP2MMP9MMP1ADAMTS4ADAMTS5 | |
| SCHEMBL7502951 | 0.78 | ADAMTS4 (0.47) | MMP2MMP9MMP1ADAMTS4ADAMTS5 | |
| SCHEMBL8000011 | 0.72 | MMP1 (0.44) | MMP2MMP9MMP1MMP13MMP14 | |
| SCHEMBL8000265 | 0.67 | MMP9 (0.55) | MMP2MMP9MMP1MMP13MMP14 | |
| SCHEMBL4009763 | 0.66 | MMP3 (0.82) | MMP3 | |
| SCHEMBL4001097 | 0.66 | MMP3 (0.82) | MMP3 | |
| SCHEMBL7506796 | 0.65 | MMP2 (0.80) | MMP2MMP9MMP1MMP3 | |
| SCHEMBL8002023 | 0.65 | MMP2 (1.00) | MMP2MMP9MMP1MMP3 | |
| SCHEMBL30504282 | 0.64 | MMP3 (0.79) | MMP3 | |
| SCHEMBL4667163 | 0.62 | MMP3 (1.00) | MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | claimed |
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |