Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Phenidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.80 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.80 |
| ▸ | ALOX5 | P09917 | 15/20 | 0.80 |
| ▸ | G6PD | P11413 | 1/20 | 0.80 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.80 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.80 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenidone SCHEMBL7999908 | 1.00 | ALOX5 (0.80) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL8470486 | 0.97 | ALOX5 (0.80) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL8470489 | 0.97 | ALOX5 (0.80) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL7999896 | 0.94 | ALOX5 (0.75) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL8470482 | 0.90 | ALOX5 (0.75) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL9281777 | 0.90 | ALOX5 (0.92) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL235192 | 0.89 | ALOX5 (1.00) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL10904906 | 0.89 | ALOX5 (1.00) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL11130362 | 0.88 | ALOX5 (0.83) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL8480957 | 0.88 | ALOX5 (0.96) | ALOX5G6PDALOX15ALOX12PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107012-A | Two-stage processing of low silver black-and-white photographic elements | EASTMAN KODAK COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| US-6040121-A | BLACK-AND-WHITE DEVELOPMENT IS CARRIED OUT IN THE FIRST STAGE FOR UP TO 30 SECONDS, AND SUCH DEVELOPMENT CONTINUES ALONG WITH FIXING IN THE SECOND STAGE FOR UP TO 60 SECONDS WHEN A FIXING COMPOSITION IS ADDED. | EASTMAN KODAK COMPANY (US) | 2000-03-21 | — | — | US | disclosed |