Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983814 | 0.86 | MAPK14 (0.57) | MAPK14TDP1MAPK13MAPK12MAPK11 | |
| SCHEMBL7996541 | 0.82 | ADORA2B (0.46) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7997004 | 0.81 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL7676429 | 0.79 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7996991 | 0.78 | CSNK1A1 (0.53) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL3164807 | 0.69 | TGFBR1 (0.54) | TDO2KMOTGFBR1MAOBCTSS | |
| SCHEMBL3231606 | 0.68 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL11976488 | 0.68 | TDO2 (0.60) | MAPK14TDP1MAPK13MAPK12MAPK11 | |
| SCHEMBL29979429 | 0.68 | TGFBR1 (0.60) | KMOTGFBR1MAOBCTSS | |
| SCHEMBL4025464 | 0.68 | TGFBR1 (0.60) | KMOTGFBR1MAOBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001057018-A1 | AZAAZULENE INHIBITORS OF P38 MAP KINASE AND TNF-ALPHA | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | claimed |
| WO-2001057018-A1 | AZAAZULENE INHIBITORS OF P38 MAP KINASE AND TNF-ALPHA | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | disclosed |