SCHEMBL8008596

SCHEMBL8008596

Cc1c(SCc2cccs2)ccnc1CCl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
HSD17B10 Q99714 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
METAP2 P50579 3/20 0.36
OPRK1 P41145 7/20 0.35
TSHR P16473 2/20 0.33
POLB P06746 2/20 0.33
PKM P14618 1/20 0.33
GBA1 P04062 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
HPGD P15428 1/20 0.32
KMT2A Q03164 1/20 0.32
TP53 P04637 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8303622 0.99 ALDH1A1 (0.37) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL7999254 0.83 ALDH1A1 (0.36) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
Hydrochloric Acid SCHEMBL8308210 0.82 CYP1A2 (0.37) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
Hydrochloric Acid SCHEMBL7007204 0.76 HSD17B10 (0.44) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
Hydrochloric Acid SCHEMBL6867811 0.76 PKM (0.43) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL7999308 0.76 ABCC8 (0.32)
SCHEMBL8307517 0.75 RAB9A (0.55) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
Hydrochloric Acid SCHEMBL8309287 0.75 ABCC8 (0.31)
SCHEMBL6865524 0.72 NPC1 (0.34) NPC1RAB9APKM
Hydrochloric Acid SCHEMBL7005381 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6107312-A BACTERICIDE BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2000-08-22 US disclosed
EP-0683776-B1 SUBSTITUTED HETEROARYLALKYLTHIOPYRIDINES FOR CONTROLLING HELICOBACTER BACTERIA BYK GULDEN LOMBERG CHEM FAB (DE) 1999-04-07 EP disclosed
EP-0764160-A1 THIOPYRIDINES FOR USE IN THE CONTROL OF HELICOBACTER BACTERIA Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1997-03-26 EP disclosed
US-5587389-A Substituted heteroarylaklylthiopyridines for controlling helicobacter bacteria BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1996-12-24 US disclosed
WO-1995034553-A1 THIOPYRIDINES FOR USE IN THE CONTROL OF HELICOBACTER BACTERIA BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1995-12-21 WO disclosed
EP-0683776-A1 SUBSTITUTED HETEROARYLALKYLTHIOPYRIDINES FOR CONTROLLING HELICOBACTER BACTERIA Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1995-11-29 EP disclosed
WO-1994019346-A1 SUBSTITUTED HETEROARYLALKYLTHIOPYRIDINES FOR CONTROLLING HELICOBACTER BACTERIA BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1994-09-01 WO disclosed