SCHEMBL8014181

SCHEMBL8014181

Cc1ccc(N(Cl)C(=O)N(C)C)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.44
TSHR P16473 1/20 0.44
SMN1; SMN2 Q16637 3/20 0.40
RAB9A P51151 2/20 0.40
MAPT P10636 3/20 0.38
MCOLN3 Q8TDD5 1/20 0.38
LMNA P02545 2/20 0.38
CES2 O00748 2/20 0.38
CES1 P23141 2/20 0.38
KDM4E B2RXH2 2/20 0.37
HTT P42858 2/20 0.37
HSD17B1 P14061 1/20 0.37
HSD17B2 P37059 1/20 0.37
KEAP1 Q14145 1/20 0.35
NFE2L2 Q16236 1/20 0.35
TP53 P04637 1/20 0.35
PKM P14618 1/20 0.34
HPGD P15428 1/20 0.34
ATM Q13315 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11508619 0.83 APP (0.39) ALDH1A1SMN1; SMN2RAB9AMAPTLMNA
SCHEMBL16435030 0.83 ALDH1A1 (0.46) ALDH1A1TSHRSMN1; SMN2RAB9AMAPT
SCHEMBL560266 0.81 NPSR1 (0.48) ALDH1A1TSHRSMN1; SMN2RAB9ALMNA
SCHEMBL11119094 0.79 LMNA (0.37) ALDH1A1TSHRSMN1; SMN2RAB9AMAPT
SCHEMBL11046065 0.78 ALDH1A1 (0.50) ALDH1A1TSHRSMN1; SMN2RAB9AMAPT
SCHEMBL3149268 0.78 LMNA (0.46) ALDH1A1TSHRSMN1; SMN2RAB9AMAPT
SCHEMBL5472705 0.78
SCHEMBL27929683 0.77 ALOX5 (0.44) ALDH1A1TSHRSMN1; SMN2RAB9AMAPT
SCHEMBL9805740 0.75 ALDH1A1 (0.47) ALDH1A1TSHRSMN1; SMN2RAB9AMAPT
SCHEMBL11676660 0.75 MLYCD (0.43) ALDH1A1TSHRSMN1; SMN2RAB9AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0600512-B1 Curable and cured organosilicon compositions HERCULES INC (US) 2000-02-09 EP disclosed
US-5552459-A FLAME RETARDANT CIBA-GEIGY CORPORATION (US) 1996-09-03 US disclosed
US-5523374-A BLEND WITH EPOXY-FUNCTIONAL COMPOUNDS; CROSSLINKING HERCULES INCORPORATED (US) 1996-06-04 US disclosed
US-5391678-A Polymerizing a mixture of polyene, silicon compound or polysiloxane having at least two SiH groups and an epoxy compound; hydrosilation; mechanical properties; electronics; molding materials; composites; prepregs; adhesives; coatings HERCULES INCORPORATED (US) 1995-02-21 US disclosed
EP-0600512-A2 Curable and cured organosilicon compositions HERCULES INCORPORATED (US) 1994-06-08 EP disclosed
US-5106947-A Moldings and coatings; nonhydrolyzing; weatherproofing; enhanced thermomechanical properties CIBA-GEIGY CORPORATION (US) 1992-04-21 US disclosed
US-4954580-A ADHESIVES, SEALING, COATING, ENCAPSULATION CIBA-GEIGY CORPORATION (US) 1990-09-04 US disclosed
US-4929273-A N-benzyl-2-(4-fluoro-3-trifluoromethylphenoxy)butanoic amide and herbicidal composition containing the same UBE INDUSTRIES, LTD. (JP) 1990-05-29 US disclosed
EP-0239414-B1 N-BENZYL-2-(4-FLUORO-3-TRIFLUOROMETHYLPHENOXY) BUTANOIC AMIDE AND HERBICIDAL COMPOSITION CONTAINING THE SAME UBE INDUSTRIES, LTD. (JP) 1989-11-02 EP disclosed
US-4724031-A CURABLE TO POLYEPOXIDES; ADHESIVES; MOLDINGS CIBA-GEIGY CORPORATION (US) 1988-02-09 US disclosed
US-4677170-A Polyepoxides and the use thereof CIBA-GEIGY CORPORATON (US) 1987-06-30 US disclosed
US-4612209-A PHOTOPOLYMERIZABLE ACRYLIC ACIDS OR ESTERS AND EPOXYIDE RESIN CIBA-GEIGY CORPORATION (US) 1986-09-16 US disclosed