Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017798 | 0.97 | MAPT (0.71) | MAPTLMNAGRM5GRM1DHODH | |
| SCHEMBL8015461 | 0.79 | LMNA (0.57) | MAPTLMNAGRM5NPC1RAB9A | |
| SCHEMBL8017383 | 0.79 | MAPT (0.71) | MAPTLMNAGRM5TDP1ALDH1A1 | |
| SCHEMBL8006281 | 0.79 | MAPT (0.60) | MAPTLMNANPC1RAB9ATDP1 | |
| SCHEMBL8019573 | 0.78 | MAPT (0.55) | MAPTLMNAGRM5NPC1RAB9A | |
| SCHEMBL13192232 | 0.76 | MAPT (0.57) | MAPTLMNATDP1ALDH1A1 | |
| SCHEMBL29152732 | 0.76 | LMNA (0.42) | MAPTLMNAGRM1ALDH1A1HPGD | |
| SCHEMBL8019313 | 0.74 | MAPT (0.48) | MAPTLMNANPC1RAB9ATDP1 | |
| SCHEMBL8022790 | 0.70 | LMNA (0.50) | MAPTLMNANPC1RAB9AFGFR1 | |
| SCHEMBL8018197 | 0.69 | MAPK14 (0.42) | MAPTLMNADHODHNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130228-A | Polycyclic compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2000-10-10 | — | — | US | disclosed |